There is an important limitation in studies on human immune responses where sampling is mainly confined to peripheral blood. However, adaptive immune reactions carry out their effects in diverse tissues.
Memory cells remain in a range of tissues, such as infection sites and lymphoid organs.
Virus-specific memory CD4+ and CD8+ T cells include heterogeneous subsets of circulating subsets and non-circulating tissue-resident memory cells in different organs.
The present study revealed the cellular complexity and functional diversity of SARS-CoV-2-specific memory T and B cells in lymphoid and mucosal tissues of previously infected organ donors up to 6 months after infection.
source: https://www.science.org/doi/10.1126/sciimmunol.abl9105#.YV864tlpefs.twitter
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