While diet, exercise, and smoking have long been recognized as important behavioral contributors to cardiovascular health, mounting evidence also implicates depression as an independent risk factor for cardiovascular disease.
Polygenic risk scores (PRS) are an increasingly available tool to refine risk prediction for cardiometabolic diseases. Favorable lifestyle behaviors might offset increased polygenic risk, but whether the frequency of depressed mood stratifies PRS-associated risk is unknown.
PRS is the quantitative representation of heritable risk for a particular trait or condition conferred by many common genetic variants. PRS are predictive of cardiometabolic disease, may identify individuals most likely to benefit from preventive therapies, and are increasingly available in clinical and direct-to-consumer settings.
Here, researchers calculated individual-level 3-million variant PRS for coronary artery disease, type 2 diabetes and atrial fibrillation among 328,152 genotyped, individuals of European ancestry in the UK Biobank.
According to data from this study, a lower frequency of depressed mood was independently associated with decreased risk of coronary artery disease and type 2 diabetes across the spectrum of polygenic risk. Further research is needed to clarify mechanisms and implications for preventive care.
Published: 14 February 2022
source:
https://www.nature.com/search?q=smoking&article_type=research&date_range=last_30_days&order=relevance
https://doi.org/10.1038/s44161-021-00011-7
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